Isotretinoin-induced vasculitis imitating polyarteritis nodosa, with perinuclear antineutrophil cytoplasmic antibody in titers correlated with clinical symptoms.

The adverse effects of retinoids on bones and joints are being increasingly documented. A case is reported in which isotretinoin was considered responsible for polyarteritis-like vasculitis. Perinuclear antineutrophil cytoplasmic antibodies were present in titers that correlated with clinical and laboratory test abnormalities.