肝细胞癌中尿转化生长因子-β1与血清甲胎蛋白的关系

Urinary transforming growth factor-beta 1 in relation to serum alpha-fetoprotein in hepatocellular carcinoma.

作者信息

Tsai J F, Jeng J E, Chuang L Y, Chang W Y, Hsieh M Y, Lin Z Y, Tsai J H

机构信息

Dept. of Internal Medicine, Kaohsiung Medical College, Taiwan.

出版信息

Scand J Gastroenterol. 1997 Mar;32(3):254-60. doi: 10.3109/00365529709000203.

DOI:10.3109/00365529709000203

PMID:9085463

Abstract

BACKGROUND

Our aim was to assess the relationship between transforming growth factor beta 1 (TGF-beta 1) and alpha-fetoprotein (AFP) levels in hepatocellular carcinoma (HCC).

METHODS

Urinary TGF-beta 1 and serum AFP were determined in 123 HCC patients, 50 patients with chronic liver disease (CLD), and 50 healthy controls.

RESULTS

Both TGF-beta 1 and AFP levels were higher in HCC patients than in CLD patients or controls (each, P = 0.0001). There was a negative correlation between TGF-beta 1 and logAFP (r = -0.196, P = 0.029). Multivariate analysis indicated that TGF-beta 1 and AFP were associated with an increased risk of HCC development. By receiver-operating characteristic curve analysis, determination of AFP and TGF-beta 1 in parallel significantly increased the sensitivity and diagnostic accuracy in detecting HCC.

CONCLUSION

Increased urinary TGF-beta 1 level can be used as a complementary marker to AFP for detection of HCC with low AFP production.

摘要

背景

我们的目的是评估肝细胞癌（HCC）中转化生长因子β1（TGF-β1）与甲胎蛋白（AFP）水平之间的关系。

方法

测定了123例HCC患者、50例慢性肝病（CLD）患者和50例健康对照者的尿TGF-β1和血清AFP。

结果

HCC患者的TGF-β1和AFP水平均高于CLD患者或对照者（均P = 0.0001）。TGF-β1与logAFP之间呈负相关（r = -0.196，P = 0.029）。多变量分析表明，TGF-β1和AFP与HCC发生风险增加相关。通过受试者工作特征曲线分析，同时测定AFP和TGF-β1可显著提高检测HCC的敏感性和诊断准确性。