Faverio L A, Piazza F M, Johnson S A, Darnell M E, Ottolini M G, Hemming V G, Prince G A
Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
J Infect Dis. 1997 Apr;175(4):932-4. doi: 10.1086/513993.
Two antigenic groups of respiratory syncytial virus (RSV) have been identified: A (RSV/A) and B (RSV/B). Topical administration of human IgG screened for high titers of antibody to RSV/A (RSVIg) is protective against RSV/A infection in the cotton rat model. The study attempted to determine if topical RSVIg would also be protective against RSV/B. Cotton rats were pretreated intranasally with RSVIg or with monospecific antiserum obtained from animals previously infected with RSV/A or RSV/B (day 0), challenged intranasally with RSV/A or RSV/B (day 1), and sacrificed for virus titration (day 5). Cotton rat antiserum to RSV/B protected against RSV/A and RSV/B, while antiserum to RSV/A protected only against RSV/A. RSVIg, although prepared on the basis of activity against RSV/A, was also protective against RSV/B.
已鉴定出呼吸道合胞病毒（RSV）的两个抗原组：A组（RSV/A）和B组（RSV/B）。经筛选具有高滴度抗RSV/A抗体（RSVIg）的人IgG局部给药，在棉鼠模型中对RSV/A感染具有保护作用。该研究试图确定局部使用RSVIg是否也能预防RSV/B感染。棉鼠在第0天经鼻用RSVIg或从先前感染RSV/A或RSV/B的动物获得的单特异性抗血清进行预处理，在第1天经鼻用RSV/A或RSV/B进行攻击，并在第5天处死以进行病毒滴定。棉鼠抗RSV/B血清对RSV/A和RSV/B均有保护作用，而抗RSV/A血清仅对RSV/A有保护作用。RSVIg虽然是基于对RSV/A的活性制备的，但对RSV/B也有保护作用。
