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溶剂的神经行为效应与昼夜节律

Neurobehavioral effects of solvents and circadian rhythms.

作者信息

Kiesswetter E, Seeber A, Blaszkewicz M, Sietmann B, Vangala R R

机构信息

Institute of Occupational Physiology, University of Dortmund, Germany.

出版信息

Neurotoxicology. 1996 Fall-Winter;17(3-4):777-84.

PMID:9086501
Abstract

Two studies on the combined neurobehavioral effects of shiftwork and solvent exposure were performed: two-shift work/mixed solvent exposure and three-shift work/single solvent exposure (acetone). Repeated measurements of exposure, body temperature, well-being, complaints, and performance were taken during each shift and during several shift cycles. The air concentrations of the solvent mixture were clearly below and of acetone were near the occupational exposure limit values. Both the exposure quality and the circadian factor contributed to the stronger adverse effects under the three-shift condition. The results support the view that exposure effects should be studied and evaluated in relation to shift and time.

摘要

开展了两项关于轮班工作与溶剂暴露综合神经行为影响的研究

两班制工作/混合溶剂暴露以及三班制工作/单一溶剂暴露(丙酮)。在每个班次以及几个轮班周期内,对暴露情况、体温、健康状况、不适主诉及工作表现进行了重复测量。溶剂混合物的空气浓度明显低于职业接触限值,丙酮的空气浓度接近职业接触限值。在三班制条件下,暴露质量和昼夜节律因素均导致了更强的不良影响。结果支持这样一种观点,即应结合轮班和时间来研究和评估暴露影响。

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