Weiner C P
Department of Obstetrics, Gynecology, Reproductive Sciences, and Physiology, University of Maryland School of Medicine, Baltimore, USA.
Obstet Gynecol Clin North Am. 1997 Mar;24(1):19-32. doi: 10.1016/s0889-8545(05)70287-4.
Two percent to four percent of all newborns have a major structural malformation of which only a small percentage can be explained by either aneuploidy or a single-gene disorder. No other mammal has a similar reproductive problem. It is the suggestion that previously unrecognized viral infection accounts for a large percentage of these abnormalities by interfering with appropriate embryonic cell migration, reducing hyperplasia, or damaging the precursor structure by means of an inflammatory mechanism.
所有新生儿中有2%至4%患有严重的结构畸形，其中只有一小部分可由非整倍体或单基因疾病解释。没有其他哺乳动物有类似的生殖问题。有一种观点认为，以前未被认识的病毒感染通过干扰胚胎细胞的正常迁移、减少细胞增生或通过炎症机制破坏前体结构，导致了这些异常情况的很大一部分。
