孕妇血清学筛查胎儿遗传性疾病。
Maternal serum screening for fetal genetic disorders.
作者信息
Ross H L, Elias S
机构信息
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA.
出版信息
Obstet Gynecol Clin North Am. 1997 Mar;24(1):33-47. doi: 10.1016/s0889-8545(05)70288-6.
Maternal serum analyte screening is an integral component of contemporary antenatal care. Based on elevated MSAFP levels, 85% to 90% of NTDs (e.g., anencephaly or spina bifida) can be detected. Using a combination of serum analytes (e.g., MSAFP, hCG, UE3) 55% to 60% of fetal Down's syndrome can be detected. Future strategies for Down's syndrome screening may include the use of new markers such as dimeric inhibin-A and urinary beta-core fragment of hCG, as well as first-trimester screening, particularly with PAPP-A and free beta-hCG.
孕妇血清分析物筛查是当代产前护理的一个重要组成部分。基于甲胎蛋白（MSAFP）水平升高，85%至90%的神经管缺陷（如无脑儿或脊柱裂）能够被检测出来。使用多种血清分析物（如MSAFP、人绒毛膜促性腺激素（hCG）、游离雌三醇（UE3））组合，55%至60%的胎儿唐氏综合征能够被检测出来。未来唐氏综合征筛查策略可能包括使用新的标志物，如二聚体抑制素A和hCG的尿β核心片段，以及孕早期筛查，尤其是联合妊娠相关血浆蛋白A（PAPP-A）和游离β-hCG进行筛查。
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