用猪蛔虫幼虫在豚鼠体内诱导产生的眼内IgE抗体。

Intraocular IgE antibody induced in guinea pigs with Ascaris suum larvae.

作者信息

Donnelly J J, Rockey J H, Soulsby E J

出版信息

Invest Ophthalmol Vis Sci. 1977 Oct;16(10):976-81.

Abstract

The systemic and local (intraocular) IgE antibody responses to infective and heat-killed Ascaris suum larvae were examined in guinea pigs. IgE antibody, demonstrated by the 6-day P-K test, was found in anterior chamber fluid following primary intravitreal injection of live second-stage A. suum larvae and in some instances occurred when no serum P-K activity was demonstrable. No intraocular IgE antibody was induced by primary intravitreal injection of heat-killed larvae. A brisk intraocular and systemic IgE antibody response followed the secondary intravitreal injection of either live or heat-killed larvae into animals systemically infected with A. suum. The guinea pig system promises to be a useful model for studying the immunopathology of human ocular parasite infections.

摘要

在豚鼠中检测了对感染性和热灭活猪蛔虫幼虫的全身及局部（眼内）IgE抗体反应。通过6天的被动皮肤过敏试验（P-K试验）证明，在初次玻璃体内注射活的二期猪蛔虫幼虫后，前房液中发现了IgE抗体，并且在某些情况下，当血清中未显示出P-K活性时也会出现。初次玻璃体内注射热灭活幼虫未诱导眼内IgE抗体产生。在全身感染猪蛔虫的动物中，二次玻璃体内注射活的或热灭活的幼虫后，出现了强烈的眼内和全身IgE抗体反应。豚鼠模型有望成为研究人类眼部寄生虫感染免疫病理学的有用模型。