房水中的非特异性免疫球蛋白E：葡萄膜炎中的评估

Nonspecific immunoglobulin E in aqueous humor: evaluation in uveitis.

作者信息

Hamel C P, De Luca H, Billotte C, Offret H, Bloch-Michel E

机构信息

Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892.

出版信息

Graefes Arch Clin Exp Ophthalmol. 1989;227(5):489-93. doi: 10.1007/BF02172904.

DOI:10.1007/BF02172904

PMID:2806935

Abstract

The levels of immunoglobulin E (IgE) in aqueous humor (AH) and serum were determined in 74 uveitis patients and 13 control patients with senile cataract. Uveitis patients' levels ranged from less than 0.06 to 460 IU/ml according to the paper radioimmunosorbent test (PRIST; limit of sensitivity, 0.06 IU/ml). Only one control patient had an AH level higher than the sensitivity limit (0.08 IU/ml). Of the five patients with the highest levels in the AH, four had toxocaral retinitis. The ratio of AH/serum to IgE normalized to the albumin concentration was calculated in 25 uveitis patients and was greater than 0.60 in 13 cases, indicating a possible intraocular IgE synthesis.

摘要

对74例葡萄膜炎患者和13例老年性白内障对照患者的房水（AH）和血清中的免疫球蛋白E（IgE）水平进行了测定。根据纸放射免疫吸附试验（PRIST；灵敏度极限为0.06 IU/ml），葡萄膜炎患者的IgE水平范围为低于0.06至460 IU/ml。只有1例对照患者的房水IgE水平高于灵敏度极限（0.08 IU/ml）。在房水IgE水平最高的5例患者中，有4例患有弓蛔虫性视网膜炎。计算了25例葡萄膜炎患者房水/血清IgE与白蛋白浓度的归一化比值，其中13例该比值大于0.60，表明可能存在眼内IgE合成。