基因疗法。未来已经到来了吗？

Gene therapy. Is the future here yet?

作者信息

Yaron Y, Kramer R L, Johnson M P, Evans M I

机构信息

Department of Obstetrics and Gynecology, Hutzel Hospital, Wayne State University, Detroit, Michigan, USA.

出版信息

Obstet Gynecol Clin North Am. 1997 Mar;24(1):179-99. doi: 10.1016/s0889-8545(05)70296-5.

DOI:10.1016/s0889-8545(05)70296-5

PMID:9086525

Abstract

Despite the overwhelming number of articles on gene therapy that have been published in the last few years, there is a paucity of trials that have successfully demonstrated the clinical usefulness of this modality. The enthusiasm characterizing some of the earlier studies has given way to a more realistic approach. The next step is to develop more efficient vectors for effective targeting and persistent gene expression.

摘要

尽管在过去几年里发表了大量关于基因治疗的文章，但成功证明这种治疗方式临床实用性的试验却很少。早期一些研究的热情已被更现实的方法所取代。下一步是开发更有效的载体，以实现有效靶向和持续的基因表达。