Kubota I, Shibata K, Onitsuka T, Koga Y
Second Department of Surgery, Miyazaki Medical College, Japan.
Surg Today. 1997;27(4):321-9. doi: 10.1007/BF00941806.
The growth of tracheal autografts and the patency of anastomotic regions were studied in 11 mongrel puppies (2.5-4 months of age, 1.9-4.3 kg in weight). Thoracic tracheal autotransplantation of 7 cartilage rings was performed. The tracheal autografts and anastomotic regions were covered with an omental pedicle flap to facilitate revascularization. Seven of the 11 dogs were evaluated for 12 months. The cross-sectional area of the lumen at the center of the tracheal autograft, as measured by thoracic computed tomography (CT), showed a significant increase from 0.37 +/- 0.11 cm2 to 1.13 +/- 0.44 cm2 after 12 months (P < 0.05). At 12 months postoperatively, all of the experimental dogs were killed, their entire tracheas were resected, and the cross-sectional areas of the anastomosis on the proximal and distal sides were measured. The cross-sectional areas at sites 5 mm apart from both anastomoses in the ungrafted trachea were measured as controls. The percent cross-sectional area (%CSA) showed good values of 67.2% +/- 19.6% on the proximal side and 85.1% +/- 12.6% on the distal side. The tracheal autografts appeared both visually and histologically viable 12 months postoperatively. This study was able to demonstrate the growth potential of the tracheal autograft in a growing puppy model.
对11只杂种幼犬（2.5 - 4月龄，体重1.9 - 4.3千克）的气管自体移植生长情况及吻合区域的通畅性进行了研究。进行了7个软骨环的胸段气管自体移植。气管自体移植物和吻合区域用带蒂网膜瓣覆盖以促进血管再生。11只犬中的7只接受了12个月的评估。通过胸部计算机断层扫描（CT）测量，气管自体移植物中心管腔的横截面积在12个月后从0.37±0.11平方厘米显著增加到1.13±0.44平方厘米（P < 0.05）。术后12个月，所有实验犬被处死，切除其整个气管，并测量吻合口近端和远端的横截面积。测量未移植气管中距两个吻合口5毫米处的横截面积作为对照。横截面积百分比（%CSA）在近端显示出良好的值，为67.2%±19.6%，在远端为85.1%±12.6%。术后12个月，气管自体移植物在肉眼和组织学上均显示存活。本研究能够在生长中的幼犬模型中证明气管自体移植物的生长潜力。
