Toyoda H, Fukuda Y, Hayakawa T
Second Department of Internal Medicine, Nagoya University, School of Medicine.
Nihon Rinsho. 1997 Mar;55(3):554-8.
We investigated the prevalence of infection of GBV-C, which has been cloned recently and is considered a parenterally transmissible virus. Ninety-one Japanese hemophiliacs who were persistently infected with HCV were evaluated. The presence of GBV-C RNA was measured by nested RT-PCR. We analyzed the prevalence and the association with subtypes of coinfected HCV. 20.9% of hemophiliacs were infected with GBV-C. The distribution of HCV subtypes of patients who are coinfected with GBV-C was similar to that of patients who are coinfected with HIV, and the prevalence of GBV-C infection of patients with HCV subtype la was significantly higher than that of patients without HCV subtype la. High prevalence of GBV-C infection was observed in Japanese hemophiliacs, and most were thought to be imported isolates from foreign origins, as well as HIV infection in these patients.
我们调查了GBV-C的感染率，该病毒最近已被克隆，被认为是一种经肠道外传播的病毒。对91名持续感染丙型肝炎病毒（HCV）的日本血友病患者进行了评估。通过巢式逆转录聚合酶链反应（nested RT-PCR）检测GBV-C RNA的存在。我们分析了GBV-C合并感染的发生率及其与HCV亚型的关联。20.9%的血友病患者感染了GBV-C。GBV-C合并感染患者的HCV亚型分布与HIV合并感染患者相似，HCV 1a亚型患者的GBV-C感染率显著高于无HCV 1a亚型的患者。在日本血友病患者中观察到GBV-C感染的高发生率，并且大多数被认为是来自国外的输入性分离株，就像这些患者中的HIV感染一样。
