Rudd J A, Naylor R J
Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong, Shatin.
Eur J Pharmacol. 1997 Mar 12;322(1):79-82. doi: 10.1016/s0014-2999(97)00073-3.
The ability of ondansetron and dexamethasone to antagonise cisplatin 10 mg/kg i.p. induced emesis was investigated in the ferret during a 24 h period. Ondansetron 0.5-5 mg/kg, as a single injection, effectively antagonised the response for approximately 4 h and revealed a subsequent response that was sensitive to further ondansetron treatment. The three times per day administration of dexamethasone 1 mg/kg i.p. alone or combined with ondansetron 1 mg/kg i.p. significantly reduced the vomiting response by 49 and 79%, respectively. The results are discussed in terms of their relevance to acute and delayed emesis in man.
在雪貂中研究了昂丹司琼和地塞米松拮抗腹腔注射10mg/kg顺铂所致呕吐的能力，观察期为24小时。单次注射0.5-5mg/kg昂丹司琼可有效拮抗呕吐反应约4小时，随后的反应对进一步的昂丹司琼治疗敏感。每天腹腔注射3次1mg/kg地塞米松单独使用或与1mg/kg腹腔注射昂丹司琼联合使用，分别使呕吐反应显著降低49%和79%。根据这些结果与人类急性和延迟性呕吐的相关性进行了讨论。
