多巴胺D4受体基因多态性：与种族的关系，在以色列受试者中与精神分裂症无关联及对氯氮平的反应
Dopamine D4 receptor gene polymorphisms: relation to ethnicity, no association with schizophrenia and response to clozapine in Israeli subjects.
作者信息
Kohn Y, Ebstein R P, Heresco-Levy U, Shapira B, Nemanov L, Gritsenko I, Avnon M, Lerer B
机构信息
Biological Psychiatry Laboratory, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
出版信息
Eur Neuropsychopharmacol. 1997 Feb;7(1):39-43. doi: 10.1016/s0924-977x(96)00380-x.
The dopamine D4 receptor (DRD4) is a candidate gene in the search for a genetic etiology of schizophrenia and for pharmacogenetic factors in the response to antipsychotic treatment. Previous work has not found linkage or association of a polymorphism in exon 3 of this gene with diagnosis of schizophrenia or response to clozapine. In this study we examined this association in Israeli schizophrenic subjects treated with clozapine, compared to ethnically matched controls. Another polymorphism of this gene, in exon 1, was also studied. Both polymorphisms showed no association with schizophrenia or treatment response. A significant difference in allelic distribution of DRD/ exon 3 polymorphism was found between Ashkenazi and non-Ashkenazi control subjects.
多巴胺D4受体（DRD4）是寻找精神分裂症遗传病因以及抗精神病治疗反应中药物遗传学因素的候选基因。先前的研究未发现该基因第3外显子的多态性与精神分裂症诊断或氯氮平反应之间存在连锁或关联。在本研究中，我们对接受氯氮平治疗的以色列精神分裂症患者与种族匹配的对照组进行了这种关联研究。该基因第1外显子的另一种多态性也进行了研究。两种多态性均与精神分裂症或治疗反应无关。在阿什肯纳兹和非阿什肯纳兹对照受试者之间发现DRD4第3外显子多态性的等位基因分布存在显著差异。
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