白虎加人参汤对支配大鼠舌下腺的自主神经纤维传出活动的影响。

Effect of byakko-ka-ninjin-to on the efferent activity of the autonomic nerve fibers innervating the sublingual gland of the rat.

作者信息

Niijima A, Kubo M, Ichiki H, Komatsu Y, Maruno M, Okada M

机构信息

Department of Physiology, Niigata University School of Medicine, Japan.

出版信息

J Auton Nerv Syst. 1997 Mar 19;63(1-2):46-50. doi: 10.1016/s0165-1838(96)00131-2.

DOI:10.1016/s0165-1838(96)00131-2

PMID:9089538

Abstract

The effect of intraduodenal infusion of Byakko-ka-ninjin-to (BN) on the efferent activity of the autonomic outflow to the sublingual gland was observed in the anesthetized rat. Intraduodenal infusion of BN (50-200 mg/kg) resulted in a dose-related increase in efferent activity. The enhancement of the nerve activity following administration of 200 mg/kg BN lasted longer than three hours. It was observed that the suppressive effect on efferent activity due to i.v. administration of hypertonic saline was antagonized by intraduodenal infusion of BN. From these observations it is suggested that Byakko-ka-ninjin-to acts as a facilitatory agent on salivary secretion.

摘要

在麻醉大鼠中观察了十二指肠内注入白虎加人参汤（BN）对舌下腺自主神经传出活动的影响。十二指肠内注入BN（50-200mg/kg）导致传出活动呈剂量相关增加。给予200mg/kg BN后神经活动的增强持续超过三小时。观察到十二指肠内注入BN可拮抗静脉注射高渗盐水对传出活动的抑制作用。从这些观察结果提示，白虎加人参汤对唾液分泌起促进作用。