Onori S, d'Errico F, De Angelis C, Egger E, Fattibene P, Janovsky I
Istituto Superiore di Sanita, Rome, Italy.
Med Phys. 1997 Mar;24(3):447-53. doi: 10.1118/1.597911.
An analysis of some of the properties of the ESR-alanine dosimetry in therapeutic proton beams is reported. Thin alanine-based detectors (1 and 2 mm thick pellets and 0.25 mm thick films) were tested in a clinical 62 MeV proton beam. The response of the alanine detectors in unmodulated and modulated proton beams was studied in tissue equivalent phantoms. The dose assessed by alanine was compared to the dose provided by a Markus parallel plate ionization chamber, used for reference dosimetry. Experiments in the 5-250 Gy dose range showed linearity of alanine dose response and no significant differences in the alanine response per unit dose to gammas and protons. Agreement within the experimental uncertainties was found between the alanine and the Markus chamber depth dose curves, including the Bragg peak region.
本文报道了对治疗性质子束中电子自旋共振-丙氨酸剂量测定法的一些特性的分析。基于丙氨酸的薄探测器（1毫米和2毫米厚的小球以及0.25毫米厚的薄膜）在临床62兆电子伏特质子束中进行了测试。在组织等效体模中研究了丙氨酸探测器在未调制和调制质子束中的响应。将丙氨酸评估的剂量与用于参考剂量测定的马克斯平行板电离室提供的剂量进行了比较。在5-250戈瑞剂量范围内的实验表明，丙氨酸剂量响应呈线性，且每单位剂量对伽马射线和质子的丙氨酸响应无显著差异。在包括布拉格峰区域在内的深度剂量曲线方面，丙氨酸和马克斯电离室在实验不确定度范围内达成了一致。
