Soon Cho E, Krause G F, Anderson H L
J Nutr. 1977 Nov;107(11):2078-89. doi: 10.1093/jn/107.11.2078.
The effects of dietary histidine and arginine on fasting and 1 and 2 hour postprandial plasma free amino acid and urea concentrations were studied in six young men. For 1 week each, they were fed six different diets containing 6.3 g of nitrogen daily. Each diet contained eight indispensable amino acids, cystine and tyrosine proportioned as in casein and a different mixture of dispensable nitrogen: A) six dispensable amino acids plus argine (diet 1) or plus histidine and arginine (diet 2) in the casein pattern, or B) an isonitrogenous amount of glycine and diammonium citrate alone (diet 3), with histidine (diet 4), with arginine (diet 5) or with histidine and arginine (diet 6). The fasting plasma concentrations of the seven indispensable amino acids assayed and their similar postprandial patterns were unaffected by the dietary treatments. Both fasting and postprandial plasma histidine concentrations were significantly lower when the histidine-low diets were fed than when the histidine-supplemented diets were fed. Histidine supplementation promoted a reduction in fasting plasma urea nitrogens. Proline concentrations were lowered significantly when proline was removed from the dietary amino acid mixtures, but plasma arginine concentrations were unaffected by arginine removal. Plasma histidine was maintained at lower concentrations in dietary histidine deficiency than when histidine was added to the low nitrogen diets.
研究了膳食组氨酸和精氨酸对6名年轻男性空腹以及餐后1小时和2小时血浆游离氨基酸及尿素浓度的影响。他们每人连续1周食用六种不同的饮食，每种饮食每天含6.3克氮。每种饮食都含有8种必需氨基酸、按酪蛋白比例配置的胱氨酸和酪氨酸以及不同的非必需氮混合物：A）酪蛋白模式下的六种非必需氨基酸加精氨酸（饮食1）或加组氨酸和精氨酸（饮食2），或B）仅含等氮量的甘氨酸和柠檬酸二铵（饮食3），加组氨酸（饮食4），加精氨酸（饮食5）或加组氨酸和精氨酸（饮食6）。所检测的七种必需氨基酸的空腹血浆浓度及其相似的餐后模式不受饮食处理的影响。与喂食补充组氨酸的饮食相比，喂食低组氨酸饮食时，空腹和餐后血浆组氨酸浓度均显著降低。补充组氨酸可促进空腹血浆尿素氮的降低。当从膳食氨基酸混合物中去除脯氨酸时，脯氨酸浓度显著降低，但去除精氨酸对血浆精氨酸浓度无影响。与在低氮饮食中添加组氨酸相比，膳食组氨酸缺乏时血浆组氨酸维持在较低浓度。
