Anderson L C, Lewis A J, Peo E R, Crenshaw J D
J Anim Sci. 1984 Feb;58(2):369-77. doi: 10.2527/jas1984.582369x.
Three experiments were conducted to determine the effects of excess arginine on performance, plasma amino acid levels and N balance of young pigs (initial weights 6.9, 7.0 and 10.3 kg, respectively). In a 28-d growth trial, various amounts of arginine (0 to 1.6%) were added to a conventional starter diet. Addition of arginine decreased (P less than .01) average daily feed intake (ADFI) and gain (ADG), but had no effect on feed efficiency (G/F). Plasma urea, arginine and ornithine concentrations were elevated (P less than .001) by the increasing dietary arginine levels at d 14 and 28. Plasma histidine levels were reduced (P less than .01) at d 28. Plasma lysine levels exhibited a cubic response (P less than .05) at d 14, but were not affected by excess arginine at d 28. In a second growth trial ADFI and ADG were decreased (P less than .05), but G/F was not affected by the addition of 1.6% dietary arginine. Lysine supplementation (0, .15 or .30%) increased performance in the absence of excess arginine, but the main effect of lysine was not significant for any performance criteria. As in the first experiment, plasma concentrations of urea, arginine and ornithine were increased (P less than .001) by the addition of arginine. Plasma histidine was not affected by either arginine or lysine. Plasma lysine levels were reduced (P less than .001) by dietary arginine and increased (P less than .001) by lysine. In a N balance experiment, addition of 1.6% dietary arginine increased N digestibility, but decreased apparent biological value. Nitrogen balance was not affected by added arginine. Lysine addition did not improve any of these three indices of N utilization. The inability of lysine supplementation to alleviate any of the adverse effects of excess arginine in young swine indicates that the reduced performance is caused by a generalized amino acid imbalance, and not by a specific interference with lysine utilization in the manner of a classical arginine-lysine antagonism.
进行了三项试验，以确定过量精氨酸对幼猪（初始体重分别为6.9、7.0和10.3千克）生产性能、血浆氨基酸水平和氮平衡的影响。在一项为期28天的生长试验中，向常规仔猪日粮中添加不同量的精氨酸（0至1.6%）。添加精氨酸降低了（P<0.01）平均日采食量（ADFI）和日增重（ADG），但对饲料效率（G/F）没有影响。在第14天和第28天，随着日粮精氨酸水平的增加，血浆尿素、精氨酸和鸟氨酸浓度升高（P<0.001）。在第28天，血浆组氨酸水平降低（P<0.01）。在第14天，血浆赖氨酸水平呈现三次方反应（P<0.05），但在第28天不受过量精氨酸的影响。在第二项生长试验中，ADFI和ADG降低（P<0.05），但添加1.6%日粮精氨酸对G/F没有影响。在没有过量精氨酸的情况下，添加赖氨酸（0、0.15或0.30%）可提高生产性能，但赖氨酸对任何生产性能指标的主要影响均不显著。与第一个试验一样，添加精氨酸可提高血浆尿素、精氨酸和鸟氨酸浓度（P<0.001）。血浆组氨酸不受精氨酸或赖氨酸的影响。日粮精氨酸降低了血浆赖氨酸水平（P<0.001），而赖氨酸则提高了血浆赖氨酸水平（P<0.001）。在一项氮平衡试验中，添加1.6%日粮精氨酸提高了氮消化率，但降低了表观生物学价值。添加精氨酸对氮平衡没有影响。添加赖氨酸并未改善这三项氮利用指标中的任何一项。在幼猪中，添加赖氨酸无法缓解过量精氨酸的任何不良影响，这表明生产性能下降是由普遍的氨基酸失衡引起的，而不是以经典的精氨酸-赖氨酸拮抗作用方式对赖氨酸利用产生特异性干扰所致。
