Whitington P F, Shermeta D W, Seto D S, Jones L, Hendrix T R
J Pediatr. 1977 Oct;91(4):550-4. doi: 10.1016/s0022-3476(77)80500-3.
The etiology of recurrent aspiration pneumonitis after the successful repair of esophageal atresia has not been defined. In order to explain this occurrence, we performed esophageal manometric examinations on eight patients who had undergone repair of EA and tracheoesophageal fistula. Two patients who had had recurrent pneumonia had subnormal pressure of the lower esophageal sphincter; they also had a history of severe regurgitation, and a barium esophagram demonstrated free gastroesophageal reflux. The LES incompetence in these patients was apparently corrected by administration of bethanechol.
食管闭锁成功修复术后反复发生误吸性肺炎的病因尚未明确。为了解释这种情况的发生，我们对8例接受食管闭锁及气管食管瘘修复术的患者进行了食管测压检查。2例反复发生肺炎的患者食管下括约肌压力低于正常；他们也有严重反流病史，钡剂食管造影显示有胃食管反流。给予氨甲酰甲胆碱后，这些患者的食管下括约肌功能不全明显得到纠正。
