Peterson R G, Rumack B H
J Pediatr. 1977 Oct;91(4):661-6. doi: 10.1016/s0022-3476(77)80528-3.
Severe poisoning resulting from single ingestions of rodenticides, herbicides, or insecticides containing arsenic have been frequently recognized. We record three cases of solubilized arsenic trioxide poisoning in Navajo Indian children and one case of sodium arsenate ingestion in an infant. One fatality occurred during dimercaprol therapy prior to initiation of therapy with D-penicillamine. Three survivors were treated with 2.3-dimercaprol intramuscularly and with oral D-penicillamine. The use of D-penicillamine in arsenic poisoning has not been generally appreciated. Excretion data from the three children are presented which document the effectiveness of D-penicillamine, administered orally in four daily doses of 25 mg/kg/dose, in the therapy of arsenic intoxication. Excretion data for the trace metals, zinc and copper, during D-penicillamine chelation therapy are also reported.
单次摄入含砷灭鼠剂、除草剂或杀虫剂导致的严重中毒已屡见不鲜。我们记录了3例纳瓦霍印第安儿童的三氧化二砷溶解中毒病例以及1例婴儿摄入砷酸钠的病例。1例患者在使用二巯丙醇治疗期间死亡，随后开始使用D-青霉胺治疗。3名幸存者接受了肌肉注射2,3-二巯丙醇并口服D-青霉胺的治疗。D-青霉胺在砷中毒治疗中的应用尚未得到普遍认可。本文给出了这3名儿童的排泄数据，这些数据证明了每日分4次口服25 mg/kg剂量的D-青霉胺在治疗砷中毒方面的有效性。本文还报告了D-青霉胺螯合治疗期间痕量金属锌和铜的排泄数据。
