蜂胶酚类成分及其合成类似物赖氨酸复合物的抗补体活性。
Anticomplement activity of lysine complexes of propolis phenolic constituents and their synthetic analogs.
作者信息
Georgieva P, Ivanovska N, Bankova V, Popov S
机构信息
Bulgarian Academy of Sciences, Institute of Microbiology, Sofia, Bulgaria.
出版信息
Z Naturforsch C J Biosci. 1997 Jan-Feb;52(1-2):60-4.
Several phenolic constituents of propolis and their synthetic analogs were derivatized with L-lysine. The ability of these complexes to alter complement activity was estimated in vitro in human serum. The influence of selected complexes on C3 hemolytic activity via classical pathway (CP) and alternative pathway (AP) and on zymosan-induced AP activation was determined. The results suppose that the anticomplement effect of the complexes might be related to the interaction with C3 complement component.
蜂胶的几种酚类成分及其合成类似物用L-赖氨酸进行了衍生化。在人血清中体外评估了这些复合物改变补体活性的能力。测定了所选复合物对经典途径（CP）和替代途径（AP）的C3溶血活性以及对酵母聚糖诱导的AP激活的影响。结果表明，这些复合物的抗补体作用可能与与C3补体成分的相互作用有关。
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