双相I型和II型障碍患者逐渐停用锂盐治疗后发病率降低：一项重复研究
Reduced morbidity after gradual discontinuation of lithium treatment for bipolar I and II disorders: a replication study.
作者信息
Baldessarini R J, Tondo L, Floris G, Rudas N
机构信息
International Consortium for Bipolar Disorder Research, MA, USA.
出版信息
Am J Psychiatry. 1997 Apr;154(4):551-3. doi: 10.1176/ajp.154.4.551.
OBJECTIVE
The aim of this study was to verify reduction of early affective morbidity by gradual, rather than rapid, discontinuation of lithium treatment.
METHOD
For 78 patients with bipolar disorders, lithium treatment was discontinued either rapidly (over 1-14 days) or gradually (over 15-30 days). The effects of the two schedules were compared by survival analysis of time to first recurrence.
RESULTS
Median time to recurrence was 5.6 times as long for gradual discontinuation (14.0 months) as for rapid discontinuation (2.5 months). The ratios of the median survival times for gradual and rapid discontinuation were similar in I and II subtypes and in depression and mania (4-6:1). The polarities of the episodes at onset and at first recurrence after lithium discontinuation were 83.6% concordant.
CONCLUSIONS
These results independently confirm a reduction in morbid risk from slow discontinuation of lithium treatment for bipolar disorders.
目的
本研究旨在验证通过逐渐而非快速停用锂盐治疗来降低早期情感性疾病的发病率。
方法
对于78例双相情感障碍患者，锂盐治疗要么快速停用（在1 - 14天内），要么逐渐停用（在15 - 30天内）。通过首次复发时间的生存分析比较两种方案的效果。
结果
逐渐停用组的复发中位时间（14.0个月）是快速停用组（2.5个月）的5.6倍。在I型和II型亚型以及抑郁和躁狂发作中，逐渐停用和快速停用的中位生存时间之比相似（4 - 6:1）。锂盐停用后首次发作和首次复发时发作的极性一致性为83.6%。
结论
这些结果独立证实了双相情感障碍患者缓慢停用锂盐治疗可降低发病风险。
Zotero 插件