Langston A A, Ostrander E A
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA.
Curr Opin Obstet Gynecol. 1997 Feb;9(1):3-7.
Ovarian cancer has been described in association with three autosomal dominant syndromes: familial site-specific ovarian cancer, familial breast and ovarian cancer, and the hereditary nonpolyposis colon cancer syndrome. It appears that most breast-ovarian and site-specific ovarian cancer families are explained by mutations in the BRCA1 tumor suppressor gene. Other genes associated with inherited susceptibility to ovarian cancer include BRCA2, p53, and the DNA mismatch repair genes.
家族性特定部位卵巢癌、家族性乳腺癌和卵巢癌以及遗传性非息肉病性结肠癌综合征。看来，大多数乳腺癌-卵巢癌和特定部位卵巢癌家族可以用BRCA1肿瘤抑制基因的突变来解释。与卵巢癌遗传易感性相关的其他基因包括BRCA2、p53和DNA错配修复基因。
