Peters M A
J Pharmacol Exp Ther. 1977 Nov;203(2):340-6.
Chronic methadone administration to female rats before, during and after gestation resulted in a delay or deficiency in brain development in their offspring compared with offspring of control rats. This deficiency in development was most noticeable as a decrease in protein and RNA content. A reduction in overall brain weight and DNA was less marked and paralleled a slight reduction in overall body weight. A comparison of the RNA/DNA and RNA/protein ratios suggested that the primary cause of the deficiency was associated with the RNA synthesis. Preliminary behavioral studies showed a significant decrease in ability of offspring of treated females to respond to a conditioning stimulus in order to avoid an electric shock. Even though upon gross observation the offspring from treated females seem normal, biochemical analysis and behavioral testing suggest that minimal brain deficiencies lasting weeks to months do occur.
在雌性大鼠妊娠前、妊娠期间及妊娠后长期给予美沙酮，与对照大鼠的后代相比，其后代的大脑发育出现延迟或缺陷。这种发育缺陷最明显的表现是蛋白质和RNA含量降低。大脑总体重量和DNA的减少不太明显，且与总体体重的轻微降低平行。RNA/DNA和RNA/蛋白质比率的比较表明，缺陷的主要原因与RNA合成有关。初步行为学研究表明，接受治疗的雌性大鼠的后代对条件刺激做出反应以避免电击的能力显著下降。尽管从总体观察来看，接受治疗的雌性大鼠的后代似乎正常，但生化分析和行为测试表明，确实会出现持续数周甚至数月的轻微脑缺陷。
