Koshy T S, Sara V R, King T L, Lazarus L
Growth. 1975 Dec;39(4):497-506.
The effect of protein restriction on fetal and placental growth was investigated. Pregnant rats were maintained on an isocaloric diet containing either 23% or 5% protein. The diet was imposed either from days 1-21 of gestation or from days 7-21 of gestation. Fetal body development was assessed. Fetal brain and placental growth were determined by both analysis of organ DNA, RNA and protein and differential radiochemical labelling procedures. Maternal protein restriction inhibited fetal growth. Brain weight was reduced due to a significant decrease in cellular content. Brain cell size was significantly increased and may have accounted for the reduction in cell concentration. Placental growth was similarly impaired. These data demonstrate impaired fetal and placental growth following decreased maternal dietary protein intake. Severity of growth retardation increased with the duration of malnutrition. The results also suggest that malnutrition may affect the rate of development, causing premature cessation of cell division and early cell differentiation.
研究了蛋白质限制对胎儿和胎盘生长的影响。将怀孕大鼠维持在含有23%或5%蛋白质的等热量饮食中。饮食限制从妊娠第1天至21天或从妊娠第7天至21天实施。评估胎儿身体发育。通过分析器官DNA、RNA和蛋白质以及差异放射化学标记程序来确定胎儿大脑和胎盘的生长。母体蛋白质限制抑制了胎儿生长。由于细胞含量显著减少，脑重量降低。脑细胞大小显著增加，这可能是细胞浓度降低的原因。胎盘生长同样受到损害。这些数据表明，母体饮食蛋白质摄入量减少后，胎儿和胎盘生长受损。生长迟缓的严重程度随着营养不良持续时间的增加而增加。结果还表明，营养不良可能影响发育速度，导致细胞分裂过早停止和早期细胞分化。
