Corey H E
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.
Pediatr Nephrol. 1997 Apr;11(2):226-30. doi: 10.1007/s004670050269.
In children, the early detection and accurate diagnosis of acute renal allograft rejection (AR) may be difficult. A delay in the diagnosis and treatment of AR might engender a poor outcome. Core needle biopsy is diagnostic but invasive. However, only a few less-invasive means to diagnose AR are sufficiently accurate to warrant their routine use. One such method is urine cytology. Investigators have demonstrated in more than 800 patients that urine cytology is simple and reliable for diagnosing graft failure. These observations may be important for children, for whom a non-invasive, accurate, and easily repeated indicator of AR may be particularly useful. While not a substitute for transplant biopsy, urine cytology may reduce diagnostic uncertainty and indicate the need for core needle sampling in a timely manner.
在儿童中，急性肾移植排斥反应（AR）的早期检测和准确诊断可能具有挑战性。AR诊断和治疗的延迟可能会导致不良后果。核心针吸活检具有诊断价值，但属于侵入性操作。然而，用于诊断AR的侵入性较小的方法中，只有少数几种足够准确，值得常规使用。尿细胞学检查就是其中一种方法。研究人员在800多名患者中证明，尿细胞学检查对于诊断移植失败简单且可靠。这些观察结果对于儿童可能很重要，因为对于他们来说，一种非侵入性、准确且易于重复的AR指标可能特别有用。虽然尿细胞学检查不能替代移植活检，但它可以减少诊断的不确定性，并及时表明进行核心针吸采样的必要性。
