Ghanta V K, Demissie S, Hiramoto N S, Hiramoto R N
Department of Biology, University of Alabama at Birmingham, 35294, USA.
Neuroimmunomodulation. 1996 Jul-Aug;3(4):233-8. doi: 10.1159/000097276.
Arecoline, a muscarinic cholinergic agonist, was found to depress body temperature and elevate the activity of preactivated natural killer (NK) cells. To demonstrate that the unconditioned responses produced by arecoline were mediated through central nervous system pathways, we used the drug as an unconditioned stimulus. By pairing camphor odor (conditioned stimulus) with arecoline (unconditioned stimulus), it was possible to simultaneously condition both a decrease in body temperature and augmentation of NK cell activity. The observations suggest that although both the modulation of body temperature and NK cell activities are integrated at the level of the hypothalamus, these pathways of regulation can be differentiated.
槟榔碱是一种毒蕈碱胆碱能激动剂，被发现可降低体温并提高预激活的自然杀伤（NK）细胞的活性。为了证明槟榔碱产生的非条件反应是通过中枢神经系统途径介导的，我们使用该药物作为非条件刺激。通过将樟脑气味（条件刺激）与槟榔碱（非条件刺激）配对，可以同时使体温降低和NK细胞活性增强这两种反应形成条件反射。这些观察结果表明，尽管体温调节和NK细胞活性调节都在下丘脑水平整合，但这些调节途径是可以区分的。
