Morrison S J, Wright D E, Cheshier S H, Weissman I L
Division of Biology, California Institute of Technology, Pasadena 91125, USA.
Curr Opin Immunol. 1997 Apr;9(2):216-21. doi: 10.1016/s0952-7915(97)80138-0.
The past year provided a number of challenges to our expectations regarding hematopoietic stem cell (HSC) biology. Evidence has emerged that HSCs arise intraembryonically before they can be detected in the yolk sac. A number of genes that may regulate the formation, self-renewal, or differentiation of HSC have been identified. New markers for purifying HSCs have also been described. Although different groups have attributed different properties to HSCs, it now appears that the differences may be explained by variations in assay conditions rather than by differences in the HSCs themselves. Finally, insights have emerged into the complexity of the regulation of HSC proliferation and adhesion properties.
过去一年，造血干细胞（HSC）生物学领域出现了诸多挑战，颠覆了我们以往的认知。有证据表明，造血干细胞在卵黄囊中被检测到之前就已在胚胎内产生。一些可能调控造血干细胞形成、自我更新或分化的基因已被识别。用于纯化造血干细胞的新标志物也已被描述。尽管不同研究团队赋予了造血干细胞不同特性，但现在看来，这些差异可能是由检测条件的不同而非造血干细胞本身的差异所导致。最后，关于造血干细胞增殖和黏附特性调控的复杂性也有了新的见解。
