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T细胞的阳性选择:挑剔还是随意?

Positive selection of T cells: fastidious or promiscuous?

作者信息

Benoist C, Mathis D

机构信息

Institut de Génétique et de Biologie Moléculaire et Cellulaire (CNRS/INSERM/ULP), Strasbourg, France.

出版信息

Curr Opin Immunol. 1997 Apr;9(2):245-9. doi: 10.1016/s0952-7915(97)80143-4.

DOI:10.1016/s0952-7915(97)80143-4
PMID:9099801
Abstract

Several studies reported during the past year, most of which exploited novel in vivo positive selection systems, have addressed the basis of peptide involvement in positive selection of T cells. The very flexible, yet specific, requirements the studies demonstrate differ somewhat from the very specific requirements reported in earlier experiments relying on in vitro selection systems.

摘要

在过去一年中报道的几项研究,其中大部分利用了新型的体内阳性选择系统,探讨了肽参与T细胞阳性选择的基础。这些研究所证明的非常灵活但又具有特异性的要求,与早期依赖体外选择系统的实验中所报道的非常具体的要求略有不同。

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Positive selection of T cells: fastidious or promiscuous?T细胞的阳性选择:挑剔还是随意?
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引用本文的文献

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Self-reactivity as the necessary cost of maintaining a diverse memory T-cell repertoire.自身反应性是维持多样化记忆性T细胞库的必要代价。
Pathog Dis. 2016 Oct;74(7). doi: 10.1093/femspd/ftw092. Epub 2016 Sep 11.
2
Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection.Grb2 在 T 细胞抗原受体诱导的酪氨酸激酶级联反应的顶端发挥作用,以控制胸腺选择。
Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10620-5. doi: 10.1073/pnas.0905039107. Epub 2010 May 24.
3
Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes.
个体肽 - Ⅱ类主要组织相容性复合体对自身MHC反应性T细胞的阳性选择。
Proc Natl Acad Sci U S A. 2002 May 14;99(10):6937-42. doi: 10.1073/pnas.102645699.
4
Review article: thymus organ cultures and T-cell receptor repertoire development.综述文章:胸腺器官培养与T细胞受体库发育
Immunology. 2000 Aug;100(4):405-10. doi: 10.1046/j.1365-2567.2000.00067.x.
5
Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4(+)CD8(+) thymocytes.在CD4(+)CD8(+)胸腺细胞的阴性选择过程中,共刺激信号是诱导转录因子Nur77所必需的。
Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):622-7. doi: 10.1073/pnas.96.2.622.
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Structural evidence of T cell xeno-reactivity in the absence of molecular mimicry.在缺乏分子模拟的情况下T细胞异种反应性的结构证据。
J Exp Med. 1999 Jan 18;189(2):359-70. doi: 10.1084/jem.189.2.359.
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Altered thymic positive selection and intracellular signals in Cbl-deficient mice.Cbl基因缺陷小鼠中胸腺阳性选择和细胞内信号的改变。
Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15547-52. doi: 10.1073/pnas.95.26.15547.
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Evidence implicating Gfi-1 and Pim-1 in pre-T-cell differentiation steps associated with beta-selection.有证据表明Gfi-1和Pim-1与前T细胞分化过程中与β选择相关的步骤有关。
EMBO J. 1998 Sep 15;17(18):5349-59. doi: 10.1093/emboj/17.18.5349.
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Modulation of thymic selection by expression of an immediate-early gene, early growth response 1 (Egr-1).通过即刻早期基因早期生长反应因子1(Egr-1)的表达对胸腺选择进行调节。
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