Meyer J, Guessous F, Huynh C, Godeau G, Hornebeck W, Giroud J P, Roch-Arveiller M
Département de Pharmacologie, Hôpital Cochin, Paris, France.
J Periodontol. 1997 Mar;68(3):256-61. doi: 10.1902/jop.1997.68.3.256.
Human leukocyte elastase is present in large amounts in the crevicular fluid of patients with periodontal disease and was considered as a putative biological marker of the evolution of such diseases. The aim of this work was to measure spectrophotometrically amounts of active elastase (AE) and elastase complexed to alpha 1 proteinase inhibitor (E-alpha 1-PI) in gingival crevicular fluid obtained, from patients suffering from rapidly progressive periodontitis (RPP group) or adult periodontitis (AP group) with different probing depths (3 to 5 mm and > 6 mm). AE and E-alpha 1-PI concentrations were negligible in healthy individuals. AE, but not E-alpha 1-PI, concentration appears to vary significantly with the probing depth in patients suffering either from rapidly progressive or adult periodontitis. No correlations were found between levels of AE and E-alpha 1-PI in the different groups of patients. AE concentration seems to be a marker of periodontal diseases in relation with probing depth.
人类白细胞弹性蛋白酶大量存在于牙周病患者的龈沟液中，被认为是此类疾病进展的一种假定生物标志物。这项工作的目的是通过分光光度法测量从患有快速进展性牙周炎（RPP组）或成人牙周炎（AP组）且具有不同探诊深度（3至5毫米和>6毫米）的患者获取的龈沟液中活性弹性蛋白酶（AE）和与α1蛋白酶抑制剂复合的弹性蛋白酶（E-α1-PI）的量。健康个体中AE和E-α1-PI的浓度可忽略不计。在患有快速进展性或成人牙周炎的患者中，AE浓度似乎随探诊深度有显著变化，而E-α1-PI浓度则不然。不同组患者的AE和E-α1-PI水平之间未发现相关性。AE浓度似乎是与探诊深度相关的牙周疾病的一个标志物。
