Yoon H, Shin Y S, Lee K C, Park H W
Department of Anatomy, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 1997 Feb;38(1):26-32. doi: 10.3349/ymj.1997.38.1.26.
Many features of the developing nervous system are visible from external observations of intact human embryos. In this study, a photographic atlas from the 4th to the 7th week after ovulation (Carnegie stages 10-18) is provided. The neural folds began to fuse at stage 10, and the rostral and caudal neuropore were closed during stages 11 and 12, respectively. The three primary divisions of the brain were distinguishable before closing of the neural tube. The five secondary brain vesicles were formed during stages 14-15. The development of the cerebellum and cerebrum were first observed at stages 14 and 15, respectively. The mesencephalic flexure was seen at stage 12, and the cervical flexure and pontine flexure at stage 14. After stages 18-19, it became increasingly difficult to identify detailed features of the brain from the surface. Results from this study will help to correlate the characteristic findings of the developing central nervous system of human embryos from stereomicroscopical and light microscopical observations and to locate the exact parts of the developing human brain for other purposes.
发育中神经系统的许多特征可以从完整人类胚胎的外部观察中看到。在本研究中，提供了排卵后第4至7周（卡内基分期10-18期）的摄影图谱。神经褶在第10期开始融合，头侧和尾侧神经孔分别在第11期和第12期闭合。在神经管闭合之前，脑的三个主要分区是可辨别的。五个次级脑泡在第14-15期形成。小脑和大脑的发育分别在第14期和第15期首次观察到。中脑曲在第12期可见，颈曲和脑桥曲在第14期可见。在第18-19期之后，从表面识别脑的详细特征变得越来越困难。本研究结果将有助于将立体显微镜和光学显微镜观察到的人类胚胎发育中中枢神经系统的特征性发现进行关联，并为其他目的定位发育中人类脑的确切部位。
