非增殖性乳腺疾病和无异型性的增殖性乳腺疾病能否通过细针穿刺细胞学检查来区分？
Can nonproliferative breast disease and proliferative breast disease without atypia be distinguished by fine-needle aspiration cytology?
作者信息
Frost A R, Aksu A, Kurstin R, Sidawy M K
机构信息
Department of Pathology, George Washington University Medical Center, Washington, DC., USA.
出版信息
Cancer. 1997 Feb 25;81(1):22-8. doi: 10.1002/(sici)1097-0142(19970225)81:1<22::aid-cncr6>3.0.co;2-i.
BACKGROUND
Cytologic criteria reported to be helpful in the distinction of proliferative breast disease without atypia (PBD) from nonproliferative breast disease (NPBD) have not been rigorously tested.
METHODS
Fifty-one air-dried, Diff-Quik-stained fine-needle aspirates (FNA) of palpable breast lesions with biopsy-proven diagnoses of NPBD (34 cases) or PBD (17 cases) were reviewed. The smears were evaluated for the cellularity, size, and architectural arrangement of the epithelial groups; the presence of single epithelial cells and myoepithelial cells; and nuclear characteristics.
RESULTS
The only cytologic feature found to be significantly different between PBD and NPBD was a swirling pattern of epithelial cells. A swirling pattern was noted in 13 of 17 PBD cases (76%) and 12 of 34 NPBD cases (35%) (P = 0.008).
CONCLUSIONS
Because there is significant overlap in cytologic features between NPBD and PBD, the distinction between the two entities is difficult in cytologic sampling.
背景
据报道，有助于区分无异型增生的乳腺增生性疾病（PBD）与非增生性乳腺疾病（NPBD）的细胞学标准尚未经过严格检验。
方法
回顾了51例经活检证实诊断为NPBD（34例）或PBD（17例）的可触及乳腺病变的风干、Diff-Quik染色细针穿刺抽吸物（FNA）。对涂片进行评估，观察上皮细胞团的细胞密度、大小和结构排列；单个上皮细胞和肌上皮细胞的存在情况；以及核特征。
结果
发现PBD和NPBD之间唯一显著不同的细胞学特征是上皮细胞的漩涡状模式。17例PBD病例中有13例（76%）出现漩涡状模式，34例NPBD病例中有12例（35%）出现漩涡状模式（P = 0.008）。
结论
由于NPBD和PBD的细胞学特征存在显著重叠，在细胞学采样中难以区分这两种实体。
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