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通过调整5-氟尿嘧啶给药时间增强辐射对小鼠肠道隐窝存活的影响。

Enhancement of radiation effect on mouse intestinal crypt survival by timing of 5-fluorouracil administration.

作者信息

Ho E, Coffey C, Maruyama Y

出版信息

Radiology. 1977 Nov;125(2):531-2. doi: 10.1148/125.2.531.

DOI:10.1148/125.2.531
PMID:910069
Abstract

There is a marked dependence of mouse crypt survival on the sequence of combined drug-radiation treatment and on the time lapse between irradiation and drug administration. When 5-fluorouracil is administered 6 hours after irradiation or later (up to 18 hours postirradiation), crypt survival drops significantly.

摘要

小鼠隐窝的存活情况明显依赖于联合药物-辐射治疗的顺序以及辐射与给药之间的时间间隔。当在辐射后6小时或更晚（辐射后长达18小时）给予5-氟尿嘧啶时，隐窝存活率会显著下降。

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