McCarthy D O, Lo C, Nguyen H, Ney D M
School of Nursing, University of Wisconsin-Madison 53792, USA.
Res Nurs Health. 1997 Apr;20(2):131-8. doi: 10.1002/(sici)1098-240x(199704)20:2<131::aid-nur5>3.0.co;2-l.
Current clinical practice emphasizes increasing calorie and protein intake to abate the nutritional decline that frequently occurs in cancer patients. Using an animal model of tumor-induced anorexia, we found that increasing the protein density of food resulted in a net increase in protein intake, but a decrease in the food intake of both healthy and tumor-bearing animals. The increased protein intake did not affect the nutritional status of tumor-bearing animals as indicated by body weight or serum levels of total protein, insulin, or insulin-like growth factor 1. These data suggest that factors regulating feeding responses to increased protein density of food are intact in hypophagic tumor-bearing rats, and that increased protein intake does not influence plasma levels of hormones requisite for protein synthesis. These data may partially explain why interventions to improve the nutritional intake of cancer patients have marginal effects on body weight, accrual of lean body mass, or synthesis of visceral proteins.
当前的临床实践强调增加热量和蛋白质摄入量，以减轻癌症患者中经常出现的营养状况下降。通过肿瘤诱导的厌食症动物模型，我们发现提高食物的蛋白质密度会导致蛋白质摄入量净增加，但健康动物和荷瘤动物的食物摄入量均减少。如体重或血清总蛋白、胰岛素或胰岛素样生长因子1水平所示，增加的蛋白质摄入量并未影响荷瘤动物的营养状况。这些数据表明，调节对食物蛋白质密度增加的进食反应的因素在食欲减退的荷瘤大鼠中是完整的，并且增加的蛋白质摄入量不会影响蛋白质合成所需激素的血浆水平。这些数据可能部分解释了为什么改善癌症患者营养摄入的干预措施对体重、瘦体重增加或内脏蛋白合成的影响甚微。
