Okazaki Y, Kano S, Ogoshi S, Ichihara K
Department of Surgery II, Kochi Medical School, Nankoku, Japan.
Coron Artery Dis. 1997 Jan;8(1):39-43. doi: 10.1097/00019501-199701000-00006.
OG-VI is a solution composed of 30 mmol/l inosine, 30 mmol/l sodium 5'-guanylate, 30 mmol/l cytidine, 22.5 mmol/l uridine, and 7.5 mmol/l thymidine, which is known to improve myocardial stunning.
To study the effect of OG-VI on myocardial energy and carbohydrate metabolism during ischemia.
Ischemia was induced in pentobarbital-anesthetized open-chested dogs for 3 min by left anterior descending coronary artery ligation. Saline, 1.2 mmol/kg per min OG-VI, or 12 mmol/kg per min OG-VI was infused at 0.1 ml/kg per min, starting 30 min before the onset of ischemia. The myocardium was extracted 3 min after the onset of ischemia, and used to determine the tissue levels of energy and carbohydrate metabolites.
Ischemia decreased the levels of ATP and fructose 1,6 diphosphate significantly, and increased those of AMP, glucose 6 phosphate, fructose 6 phosphate and lactate. OG-VI infusion preserved the adenine nucleotide levels significantly in 3 min ischemic hearts, and attenuated the ischemia-induced alteration of carbohydrate metabolism.
OG-VI may improve the myocardial metabolic derangement induced by ischemia.
OG-VI是一种由30 mmol/L肌苷、30 mmol/L 5'-鸟苷酸钠、30 mmol/L胞苷、22.5 mmol/L尿苷和7.5 mmol/L胸苷组成的溶液，已知其可改善心肌顿抑。
研究OG-VI对缺血期间心肌能量和碳水化合物代谢的影响。
通过结扎左冠状动脉前降支，在戊巴比妥麻醉的开胸犬中诱导缺血3分钟。在缺血开始前30分钟，以0.1 ml/kg每分钟的速度输注生理盐水、1.2 mmol/kg每分钟的OG-VI或12 mmol/kg每分钟的OG-VI。缺血开始3分钟后取出心肌，用于测定能量和碳水化合物代谢物的组织水平。
缺血显著降低了ATP和1,6-二磷酸果糖的水平，并提高了AMP、6-磷酸葡萄糖、6-磷酸果糖和乳酸的水平。输注OG-VI可显著维持3分钟缺血心脏中的腺嘌呤核苷酸水平，并减轻缺血诱导的碳水化合物代谢改变。
OG-VI可能改善缺血诱导的心肌代谢紊乱。
