Harnois D M, Lindor K D
Mayo Clinic, Rochester, Minn 55905, USA.
Dig Dis. 1997 Jan-Apr;15(1-2):23-41. doi: 10.1159/000171586.
Primary sclerosing cholangitis is an increasingly recognized cause of chronic cholestatic liver disease. The etiology is unknown, although a number of immunologic and nonimmunologic factors have been considered. The most important diagnostic findings are diffuse irregularity and narrowing of extrahepatic and intrahepatic bile ducts. The prognosis varies, and a number of relatively unique complications may develop. No adequate treatment exists, although a number of potential treatments have been evaluated. Liver transplantation still remains the most appropriate treatment for end-stage disease. These various topics related to primary sclerosing cholangitis are reviewed.
原发性硬化性胆管炎是慢性胆汁淤积性肝病中一种日益受到认可的病因。尽管已经考虑了许多免疫和非免疫因素，但其病因尚不清楚。最重要的诊断发现是肝外和肝内胆管弥漫性不规则和狭窄。预后各不相同，可能会出现一些相对独特的并发症。虽然已经评估了许多潜在的治疗方法，但目前尚无足够有效的治疗方法。肝移植仍然是终末期疾病最适当的治疗方法。本文对与原发性硬化性胆管炎相关的这些不同主题进行了综述。
