Mielke G, Steil E, Gonser M
Department of Obstetrics and Gynecology, University of Tübingen, Germany.
Fetal Diagn Ther. 1997 Jan-Feb;12(1):46-9. doi: 10.1159/000264426.
Antenatal stenosis or closure of the ductus arteriosus unrelated to either congenital heart defects or prostaglandin inhibitors is considered to be uncommon, but may result in congestive heart failure, hydrops fetalis, and perinatal death. We report a case of idiopathic ductal stenosis detected prenatally by two-dimensional and Doppler echocardiography in a fetus presenting atrial flutter and right atrial dilatation at 31 weeks of gestation. Prenatal treatment with digoxin and verapamil resulted in conversion to sinus rhythm. The fetus was closely monitored. Congestive heart failure did not develop, and the fetus was delivered spontaneously in good condition at 39 weeks of gestation. In case of ductal stenosis, the potential risk of congestive heart failure must be considered, and maternal administration of drugs with constrictive effects on the ductus arteriosus, as indomethacin or betamethasone, should be avoided.
产前动脉导管狭窄或闭合,若与先天性心脏缺陷或前列腺素抑制剂无关,则被认为较为罕见,但可能导致充血性心力衰竭、胎儿水肿和围产期死亡。我们报告一例特发性导管狭窄病例,在妊娠31周时,通过二维和多普勒超声心动图在一名出现心房扑动和右心房扩张的胎儿中产前检测到。地高辛和维拉帕米的产前治疗导致转为窦性心律。对胎儿进行了密切监测。未发生充血性心力衰竭,胎儿在妊娠39周时自然分娩,情况良好。对于导管狭窄病例,必须考虑充血性心力衰竭的潜在风险,应避免母体使用对动脉导管有收缩作用的药物,如吲哚美辛或倍他米松。