Remy J, Deschildre F, Artaud D, Remy-Jardin M, Copin M C, Bordet R, Gosselin B
Department of Radiology, Hospital Calmette, University Hospital Center, Lille, France.
Invest Radiol. 1997 Apr;32(4):218-24. doi: 10.1097/00004424-199704000-00005.
The authors study the bronchial arteries in the adult pig before and after pulmonary artery occlusion.
The bronchial artery anatomy was analyzed on postmortem aortograms in six pigs in group 1. In 20 animals in group 2, the left diaphragmatic lobar pulmonary artery (DLPA) was proximally (n = 12), medially (n = 5), or distally (n = 3) occluded via angiographic procedures; an unintentional embolization of coils in the right DLPA led to an incomplete pulmonary arterial occlusion. Eight to 12 weeks later, postmortem bronchial angiograms and pathologic studies were performed systematically in group 2.
Outcomes in group 1 were: (A) a common trunk to the right and left bronchial arteries found in five animals, and (B) bronchopulmonary anastomoses found in the five lungs optimally injected. Outcomes in group 2 were: (A) the absence of pulmonary infarct and the development of a collateral bronchial supply were constant in the left lung; (B) the left DLPAs were patent beyond the coils and opacified via bronchopulmonary anastomoses; (C) dilated subpleural bronchial arteries were constant in the interlobular septa of the lung parenchyma devoid of pulmonary arterial perfusion; (D) the right bronchial arteries were normal after incomplete pulmonary artery occlusion.
Because of an anastomosed dual circulation, the pig is a reliable experimental model for interventional and surgical procedures.
作者研究成年猪肺动脉闭塞前后的支气管动脉。
对第1组6头猪的尸检主动脉造影进行支气管动脉解剖分析。在第2组20只动物中，通过血管造影术将左膈叶肺动脉（DLPA）在近端（n = 12）、中部（n = 5）或远端（n = 3）闭塞；右DLPA中线圈的意外栓塞导致肺动脉不完全闭塞。8至12周后，对第2组进行系统的尸检支气管血管造影和病理研究。
第1组的结果为：（A）5只动物中发现左右支气管动脉有共同主干，（B）在5只最佳注射的肺中发现支气管肺吻合。第2组的结果为：（A）左肺无肺梗死且出现支气管侧支供血；（B）左DLPA在线圈之外通畅并通过支气管肺吻合显影；（C）在无肺动脉灌注的肺实质小叶间隔中，胸膜下支气管动脉扩张是恒定现象；（D）肺动脉不完全闭塞后右支气管动脉正常。
由于存在吻合的双重循环，猪是介入和外科手术的可靠实验模型。
