表达猫疱疹病毒1型血凝素（gD）的昆虫细胞与猫细胞系的黏附。

Adhesion of insect cells expressing the feline herpesvirus type 1 hemagglutinin (gD) to feline cell lines.

作者信息

Maeda K, Ono M, Kawaguchi Y, Okazaki K, Yokoyama N, Tohya Y, Mikami T

机构信息

Department of Veterinary Microbiology, Faculty of Agriculture, University of Tokyo, Japan.

出版信息

J Vet Med Sci. 1997 Mar;59(3):217-9. doi: 10.1292/jvms.59.217.

DOI:10.1292/jvms.59.217

PMID:9101483

Abstract

Feline herpesvirus type 1 (FHV-1) gD-expressing Sf9 cells adhered to two feline cell lines, but not to the porcine, bovine, or canine cell lines tested. In addition, this adhesion activity was inhibited by a monoclonal antibody against FHV-1 gD. These results showed that the FHV-1 gD might bind to a specific-molecule(s) on the surface of feline cell lines. We discussed a possible importance of the FHV-1 gD in host cell restriction to FHV-1 infection.

摘要

表达猫疱疹病毒1型（FHV-1）gD的Sf9细胞能黏附于两种猫细胞系，但不能黏附于所测试的猪、牛或犬细胞系。此外，这种黏附活性被抗FHV-1 gD单克隆抗体抑制。这些结果表明，FHV-1 gD可能与猫细胞系表面的特定分子结合。我们讨论了FHV-1 gD在宿主细胞对FHV-1感染的限制中可能具有的重要性。