Naveh Y, Schapira D, Ravel Y, Geller E, Scharf Y
Department of Pediatrics, Rambam Medical Center, Haifa, Israel.
J Rheumatol. 1997 Apr;24(4):643-6.
To study zinc absorption in patients with active rheumatoid arthritis (RA).
We studied zinc tolerance tests and 24 hour urinary zinc excretion before and after ingestion of 50 mg elemental zinc in 8 healthy volunteers (Group 1) and 13 patients with low RA activity (Group 2) and 16 patients with high RA activity (Group 3).
In Group 1, plasma zinc rose from 111 +/- 7 micrograms/dl to a peak of 200 +/- 24 micrograms/dl (mean +/- SEM) in 2 h. In Groups 2 and 3, plasma zinc before zinc ingestion was significantly lower than that of the control group (p < 0.00001 for both groups) and showed no significant increase in plasma after ingestion. Twenty-four hour urinary zinc excretions before and after zinc ingestion were significantly lower (p < 0.01, p < 0.0001 for Group 2; p < 0.05, p < 0.01 for Group 3, respectively) than those in the control group.
These results are compatible with zinc malabsorption and consequent zinc deficiency in patients with RA. Whether zinc deficiency contributes to perpetuation of disease activity by compromising cellular immune function needs further investigation.
研究活动期类风湿关节炎（RA）患者的锌吸收情况。
我们对8名健康志愿者（第1组）、13名低疾病活动度RA患者（第2组）和16名高疾病活动度RA患者（第3组）进行了锌耐量试验，并测定了摄入50毫克元素锌前后24小时尿锌排泄量。
在第1组中，血浆锌在2小时内从111±7微克/分升升至峰值200±24微克/分升（均值±标准误）。在第2组和第3组中，摄入锌前的血浆锌显著低于对照组（两组均p<0.00001），摄入后血浆锌无显著增加。第2组和第3组摄入锌前后24小时尿锌排泄量均显著低于对照组（第2组分别为p<0.01、p<0.0001；第3组分别为p<0.05、p<0.01）。
这些结果与RA患者锌吸收不良及由此导致的锌缺乏相符。锌缺乏是否通过损害细胞免疫功能导致疾病活动持续存在尚需进一步研究。
