von Schweinitz D, Fuchs J, Mildenberger H
Abteilung für Kinderchirurgie, Medizinische Hochschule, Hannover.
Langenbecks Arch Chir Suppl Kongressbd. 1996;113:1091-4.
The therapeutic results of two groups of children with liver tumours were compared: group 1 [29 hepatoblastomas (HB) and five liver carcinomas (HCC)] were operated before 1987, and group 2 (88 HB and 16 HCC) were treated according to the studies HB 89 and HB 94 of the GPOH from 1988 onwards. Resection rates for HB were 81% (group 1) and 93% (group 2), with tumour-free survival rates of 38% and 77%, respectively: anatomic liver resections were more often radical than atypical tumour resections. Resections of lung metastases and liver transplantations increased tumour-free survival. In HCC therapeutic results were equally poor (25% cure). Thus in HB combined chemotherapy and surgery is highly effective, but HCCs are cured only by radical resections.
第一组[29例肝母细胞瘤（HB）和5例肝癌（HCC）]于1987年之前接受手术，第二组（88例HB和16例HCC）自1988年起根据德国儿童肿瘤学研究组（GPOH）的HB 89和HB 94研究进行治疗。HB的切除率分别为81%（第一组）和93%（第二组），无瘤生存率分别为38%和77%：解剖性肝切除术比非典型肿瘤切除术更常为根治性手术。肺转移灶切除术和肝移植提高了无瘤生存率。在HCC中，治疗效果同样很差（治愈率为25%）。因此，在HB中，联合化疗和手术非常有效，但HCC仅通过根治性切除才能治愈。
