Knoch M, Hohenberger W
Chirurgische Klinik, Universitätsklinik Erlangen.
Langenbecks Arch Chir Suppl Kongressbd. 1996;113:133-5.
In a total of 1073 unradically resected patients (R1/R2) surprisingly we found a group of 31 with a more than 5-year-survival and seven patients living more than 10 years. The prognosis in patients presenting rectal carcinoma was significantly better compared to colon cancer, with a 5-year-survival of 5 +/- 2% compared to 1 +/- 1%. For a long local control of tumor growth in the residual tumor patients, the possibility of irradiation probably in combination with chemotherapy seems to explain these data; but half of our longterm survivors had no additional therapy. The influence of tumorbiological and immunological factors in such patients are of further interest.
在总共1073例未行根治性切除的患者（R1/R2）中，令人惊讶的是，我们发现一组31例患者存活时间超过5年，7例患者存活时间超过10年。与结肠癌相比，直肠癌患者的预后明显更好，5年生存率为5±2%，而结肠癌为1±1%。对于残留肿瘤患者的肿瘤生长进行长期局部控制，放疗可能联合化疗的可能性似乎可以解释这些数据；但我们一半的长期存活者没有接受额外治疗。此类患者中肿瘤生物学和免疫因素的影响更值得关注。
