Schwarzbach M, Willeke F, Eble M, Lehnert T, Ewerbeck V, Wannenmacher M, Herfarth C
Chirurgische Universitätsklinik, Heidelberg.
Langenbecks Arch Chir Suppl Kongressbd. 1996;113:214-7.
Radical or wide excision is the treatment of choice for soft-tissue sarcomas (STS) of the extremities. Multimodality therapy made limb-sparing surgery possible. While external beam radiotherapy is well established in this setting, few data are available about intraoperative radiotherapy (IORT). We performed an analysis of 36 patients treated with IORT and external beam radiation following resection of STS of the extremities between 1991 and 1995. Only STS classified as UICC stage IIb, III or IV were included. Operative morbidity was 17%, 14% showed late complications. Within a mean follow-up of 24 months (min. 6), there was one local recurrence in 30 patients treated curatively. The 3-year survival rate of patients treated curatively was 75%; 3-year recurrence-free survival was 65%.
根治性或广泛切除是四肢软组织肉瘤（STS）的首选治疗方法。多模式治疗使保肢手术成为可能。虽然外照射放疗在这种情况下已得到充分确立，但关于术中放疗（IORT）的数据却很少。我们对1991年至1995年间接受四肢STS切除术后接受IORT和外照射放疗的36例患者进行了分析。仅纳入分类为UICC IIb期、III期或IV期的STS。手术并发症发生率为17%，14%出现晚期并发症。在平均24个月（最短6个月）的随访中，30例接受根治性治疗的患者中有1例局部复发。接受根治性治疗的患者3年生存率为75%；3年无复发生存率为65%。
