Lisitsyna T A, Ivanova M M, Durnev A D
Vestn Ross Akad Med Nauk. 1996(12):15-20.
In this paper the authors underline the significance of studies into the body's free radical oxidation, analyze the involvement of free radical reactions in the maintenance of homeostasis. They indicate that free radical metabolic changes leading to oxidative stress play a role in the pathogenesis of many human diseases. Particular emphasis is laid on the contribution of active forms of oxygen (AFO) in the development of autoimmune diseases, including rheumatic diseases. The history of this problem is outlined. There are examples that confirm the enhancement of free radical processes and the inhibition of the antioxidative system in rheumatic arthritis (RA) and some other rheumatic diseases. The essential drugs used in the treatment of RA patients are demonstrated to also act due to the inhibited "respiratory outbreak" of phagocytes. The key point of the paper is the role of free radical reactions in the pathogenesis of systemic lupus erythematosus (SLE). There is evidence suggesting that there is a reduction in antioxidative defense and a rise in neutrophilic production of AFO in SLE patients. Consideration is also given to the possible participation of AFO in the formation of DNA antibodies, the effects of AFO on the immune system, atherogenesis in SLE. Taking into account a possible contribution of AFO in the pathogenesis of SLE, it is expedient to include antiradical agents into the multimodality therapy for this disease and promising to continue investigations in this field.
在本文中，作者强调了对机体自由基氧化研究的重要性，分析了自由基反应在维持体内稳态中的作用。他们指出，导致氧化应激的自由基代谢变化在许多人类疾病的发病机制中起作用。特别强调了活性氧（AFO）在自身免疫性疾病（包括风湿性疾病）发展中的作用。概述了该问题的历史。有实例证实，在风湿性关节炎（RA）和其他一些风湿性疾病中，自由基过程增强，抗氧化系统受到抑制。已证明用于治疗RA患者的主要药物也是通过抑制吞噬细胞的“呼吸爆发”而起作用的。本文的重点是自由基反应在系统性红斑狼疮（SLE）发病机制中的作用。有证据表明，SLE患者的抗氧化防御能力下降，中性粒细胞产生AFO的能力增强。还考虑了AFO在DNA抗体形成中的可能作用、AFO对免疫系统的影响、SLE中的动脉粥样硬化形成。考虑到AFO在SLE发病机制中的可能作用，在该疾病的多模式治疗中加入抗自由基药物是适宜的，并且在该领域继续开展研究很有前景。
