[Analysis of polymorphism of the hypervariable locus of the apolipoprotein-B gene in populations of the Volga-Ural region].

Data on the allelic polymorphism at the hypervariable locus 3' to the apolipoprotein B gene (apo B) in seven Turkic and Finno-Ugric human populations of the Volga-Ural region obtained by means of PCR method are presented. Sixteen allelic variants were distinguished, and the frequency distribution of alleles and genotypes across the populations studied were estimated. Alleles 34 and 36 appeared to be more common (from 13 to 45% in different populations); the calculated heterozygosity indices ranged from 59.3 to 73.4%. Comparison of the data with that on other world populations made it possible to deduce some specific features of the alleles frequency distribution associated with geographic position of the population.