Khusnutdinova E K, Viktorova T V, Khidiiatova I M, Fatkhlislamova R I, Ivashchenko T E
Genetika. 1997 Sep;33(9):1291-6.
Data on allelic polymorphism of MET and D7S23 DNA loci linked to the human cystic fibrosis gene studied in three Bashkir ethnic groups and some Volga-Ural populations (Tartars, Maris, Mordovians, Udmurts, Chuvashs, and Komis) are presented. Udmurts were found to be substantially different from Bashkirs, Tartars, Mordovians, and Chuvashs by the allele frequency distribution observed for MET, while Komis and Bashkirs differed by this parameter from Mordovians and Maris. Comparative analysis of restriction fragment length polymorphism (RFLP) at the D7S23 locus revealed statistically significant differences in genotype frequencies between Bashkirs of the Arkhangel' skii region and populations of Mordva and Udmurtia. In this respect, the Mordovian population appeared to be notably different from the populations of Bashkortostan, Tatarstan, Marii-El, Udmurtiya, Chuvashiya, and Komis. Genetic distances were calculated and corresponding dendrograms were constructed on the basis of data on Met-H, CS.7, and the ApoB locus hypervariable region allelic frequencies. Three ethnogeographic Bashkir groups belonging to one tree branch were found to be closely related to the populations of Tartars, Maris, Udmurts, and Chuvashs and substantially different from Komis and Mordovians. Thus, the position of Volga-Ural populations on the dendrogram corresponds to the degree of relationship between the Finno-Ugric and Turkic populations, confirming the usefulness of DNA polymorphism analysis for the study of the genetic structure of populations.
本文展示了在三个巴什基尔民族群体以及一些伏尔加 - 乌拉尔人群（鞑靼人、马里人、莫尔多瓦人、乌德穆尔特人、楚瓦什人以及科米人）中研究的与人类囊性纤维化基因相关的MET和D7S23 DNA位点的等位基因多态性数据。通过观察MET的等位基因频率分布发现，乌德穆尔特人与巴什基尔人、鞑靼人、莫尔多瓦人和楚瓦什人有显著差异，而科米人和巴什基尔人在该参数上与莫尔多瓦人和马里人不同。对D7S23位点的限制性片段长度多态性（RFLP）进行比较分析发现，阿尔汉格尔斯克地区的巴什基尔人与莫尔多瓦和乌德穆尔特地区人群的基因型频率存在统计学上的显著差异。在这方面，莫尔多瓦人群与巴什科尔托斯坦、鞑靼斯坦、马里埃尔、乌德穆尔特、楚瓦什和科米地区的人群明显不同。基于Met - H、CS.7以及载脂蛋白B位点高变区等位基因频率的数据计算了遗传距离并构建了相应的树状图。发现属于一个树枝分支的三个民族地理巴什基尔群体与鞑靼人、马里人、乌德穆尔特人和楚瓦什人的群体密切相关，与科米人和莫尔多瓦人有显著差异。因此，伏尔加 - 乌拉尔人群在树状图上的位置与芬兰 - 乌戈尔和突厥人群之间的亲缘关系程度相对应，证实了DNA多态性分析在研究人群遗传结构方面的有用性。
