Grigorenko E L, Shikanian A A, Kidd D R, Dorig R, Kidd K K
Yale University, Department of Genetics, New Haven 06520, USA.
Genetika. 1996 Dec;32(12):1705-13.
A program that simulates random genetic drift, random mating, recombination, natural selection, and mutation process was developed to study the influence of these processes on the evolutionary dynamics of haplotype frequencies in populations. The program can track nine sites, each including up to 15 alleles. The program application was illustrated by the study of frequency dynamics in the HOXB haplotypes (17q) in different populations. The simulation results confirmed the hypothesis, which was proposed on the basis of the experimental data, that, in the absence of recurrent mutations, population mixing, and natural selection, the harmonic mean of the effective population size from the moment of New World colonization up to now was more than 1000.
开发了一个模拟随机遗传漂变、随机交配、重组、自然选择和突变过程的程序，以研究这些过程对群体中单倍型频率进化动态的影响。该程序可以追踪9个位点，每个位点最多包含15个等位基因。通过对不同群体中HOXB单倍型（17q）频率动态的研究来说明该程序的应用。模拟结果证实了基于实验数据提出的假设，即在没有反复突变、群体混合和自然选择的情况下，从新大陆殖民到现在有效群体大小的调和平均值超过1000。
