Eisman J A, Wark J D, Prince R L, Moseley J M
Lancet. 1979 Nov 3;2(8149):931-3. doi: 10.1016/s0140-6736(79)92624-2.
In normal volunteers infusion of parathyroid extract raised plasma 1,25-dihydroxyvitamin D (1,25-[OH]2D) levels by 80% (peak 8--40 h after infusion) without producing any significant change in plasma calcium, phosphate, or magnesium. An oral calcium load suppressed plasma 1,25-(OH)2D to 63% of control values within 48--72 h. These responses will be useful in the diagnosis and management of disturbances of calcium and mineral metabolism in which vitamin D metabolism is abnormal.
在正常志愿者中，输注甲状旁腺提取物可使血浆1,25 - 二羟维生素D（1,25 - [OH]2D）水平升高80%（输注后8 - 40小时达到峰值），而血浆钙、磷或镁水平无任何显著变化。口服钙负荷在48 - 72小时内可将血浆1,25 - (OH)2D抑制至对照值的63%。这些反应对于诊断和处理维生素D代谢异常的钙和矿物质代谢紊乱将很有用。
