Santagostino G, Messeri E, Tonelli M, Veneziani A
U.O. Anestesia e Rianimazione, Nuovo Ospedale San Giovanni di Dio, Azienda USL n. 10, Firenze.
Minerva Anestesiol. 1996 Dec;62(12):389-94.
High concentrations of intrathecal local anaesthetics may be neurotoxic. The purpose of this study was to compare the features of superselective spinal anaesthesia (ASS) obtained with an equivalent dose (5 mg) of 0.5% (available now also in Italy) and 1% hyperbaric bupivacaine.
A prospective study was carried out on 100 patients undergoing saphenectomy, who were randomized into two groups to receive either 0.5% bupivacaine 1 ml (group A) or 1% bupivacaine 0.5 ml (group B). The anaesthetic solution was injected 1 ml/min at L2-L3 with an atraumatic needle. During dural puncture and following 20 minutes patients were held with the operative side down. In every patient were recorded: quality and level of analgesia on dependent (operative) and non dependent sides; motor-block at the 20th minute and 2nd, 3rd and 4th hours on both sides; reduction per cent of systolic artery pressure (SAP) and heart rate (HR), incidence of hypotension (SAP < 90 mmHg) and bradycardia (HR < 50 bts/min); recovery of deambulation and micturition and side effects.
Significant differences between the two groups have been found in: 1) number of thoracic segments blocked (3.22 vs 2.02); 2) motor block at the 2nd hour; 3) number of patients able to walk (19 vs 3) and to micturate (11 vs 3) at the 2nd hour.
0.5% hyperbaric bupivacaine can be successfully use in ASS; early regression of motor block is especially suitable for the requirements of day surgery.
鞘内注射高浓度局部麻醉药可能具有神经毒性。本研究的目的是比较使用等效剂量(5毫克)的0.5%(意大利现也有售)和1%重比重布比卡因获得的超选择性脊髓麻醉(ASS)的特点。
对100例行大隐静脉切除术的患者进行前瞻性研究,将其随机分为两组,分别接受1毫升0.5%布比卡因(A组)或0.5毫升1%布比卡因(B组)。使用无创伤针以1毫升/分钟的速度在L2-L3处注射麻醉溶液。在硬膜穿刺期间及之后20分钟,让患者手术侧朝下。记录每位患者的以下情况:患侧(手术侧)和非患侧的镇痛质量和平面;两侧在第20分钟以及第2、3和4小时的运动阻滞情况;收缩压(SAP)和心率(HR)的下降百分比、低血压(SAP<90毫米汞柱)和心动过缓(HR<50次/分钟)的发生率;步行和排尿功能的恢复情况以及副作用。
两组之间在以下方面存在显著差异:1)阻滞的胸段数量(3.22对2.02);2)第2小时的运动阻滞情况;3)第2小时能够行走(19对3)和排尿(11对3)的患者数量。
0.5%重比重布比卡因可成功用于超选择性脊髓麻醉;运动阻滞的早期消退特别适合日间手术的需求。