Lozance L, Zafirovska K, Bogdanovska S, Masin-Paneva J
Clinic of Nephrology, Medical Faculty, Skopje, Macedonia.
Srp Arh Celok Lek. 1996;124 Suppl 1:197-9.
In 24 young normotensive subjects (mean age 22.25 +/- 5.65 years) with one hypertensive parent (FH(+)-), 22 subjects (mean age 23.55 +/- 5.17 years) with two hypertensive parents (FH+ +/-), and a control group of 16 age and gender matched subjects (mean age 22.50 +/- 6.00 years) with two normotensive parents (FH--), creatinine clearances and microalbuminuria (MA) were measured. Blood pressure was monitored for 24 hours and mean arterial pressure (MAP) was calculated and compared between groups. No significant differences were recorded. FH(+)- and FH++ subjects had significantly higher MAP over the sleeping period than FH-- subjects (78.63 +/- 1.71, 78.95 +/- 1.27; and 72.91 +/- 1.35 mmHg respectively; p < 0.02). Creatinine clearance was higher in FH(+)- and FH++ group compared to FH-- subjects (2.39 +/- 0.17; 2.29 +/- 0.17; and 1.66 +/- 0.11 ml/sec respectively; p < 0.01). Hyperfiltration correlated with MAP in FH++ subjects (2.29 +/- 0.17 ml/sec; 92.45 +/- 7.39 mmHg; r = 0.52 i p < 0.03). MA correlated neither with creatinine clearance nor with MAP. Our results suggest that hypertension may develop as a consequence of the long-lasting, higher GFR, which may accelerate the age-related process of sclerosis both in the small arterioles and the glomeruli.
在24名有一位高血压父母的年轻血压正常受试者（平均年龄22.25±5.65岁，FH(+)-）、22名有两位高血压父母的受试者（平均年龄23.55±5.17岁，FH+ +/-）以及16名年龄和性别匹配、有两位血压正常父母的对照组受试者（平均年龄22.50±6.00岁，FH--）中，测量了肌酐清除率和微量白蛋白尿（MA）。监测24小时血压，计算平均动脉压（MAP）并在组间进行比较。未记录到显著差异。FH(+)-和FH++受试者在睡眠期间的MAP显著高于FH--受试者（分别为78.63±1.71、78.95±1.27和72.91±1.35 mmHg；p<0.02）。与FH--受试者相比，FH(+)-和FH++组的肌酐清除率更高（分别为2.39±0.17；2.29±0.17和1.66±0.11 ml/秒；p<0.01）。在FH++受试者中，高滤过与MAP相关（2.29±0.17 ml/秒；92.45±7.39 mmHg；r = 0.52，p<0.03）。MA与肌酐清除率和MAP均无相关性。我们的结果表明，高血压可能是长期较高肾小球滤过率（GFR）的结果，这可能会加速小动脉和肾小球中与年龄相关的硬化进程。
