Mitić I, Fele D, Lenert P, Curić S, Vodopivec S, Bozić D, Sakac V, Djisalov M, Ilić T, Sebić L, Djurdjević-Mirković T, Tepavcević P
Clinic of Nephrology and Clinical Immunology, Institut of Internal Diseases, Novi Sad.
Srp Arh Celok Lek. 1996;124 Suppl 1:67-9.
Renal involvement i.e. lupus nephritis (LN) in systemic lupus erythematosus (SLE) mainly determines course and outcome of the disease. Recognition of early manifestations of LN makes adequate therapy possible, with very good therapeutic results. We report 7 patients from a group of 150 SLE patients under our permanent control, 4 female and 3 male, mean age 21 years. All of them had signs of LN: proteinuria 7/7 haematuria 4/7 without azotaemia. Renal biopsy was performed in 6 pts, and histological finding was: class II 1 pt, class IV 3 pts and class V in 2 pts. In 4 pts tubulointerstitial changes were noted, while all showed immunofluorescent deposits of immunoglobulins and complement. Methylprednisolone "pulse" therapy (1000 mg, i.v., 3 days) followed by tapering of the steroid dose was given. Reduction of proteinuria and disappearance of haematuria were observed in all patients. During follow up, kidney function remained normal.
肾脏受累，即系统性红斑狼疮（SLE）中的狼疮性肾炎（LN），主要决定了该疾病的病程和预后。识别LN的早期表现可使适当治疗成为可能，并取得非常好的治疗效果。我们报告了在我们长期随访的150例SLE患者中选取的7例患者，4例女性，3例男性，平均年龄21岁。他们均有LN的体征：蛋白尿7例中有7例，血尿7例中有4例，无氮质血症。6例患者进行了肾活检，组织学结果为：Ⅱ级1例，Ⅳ级3例，Ⅴ级2例。4例患者出现肾小管间质改变，所有患者均显示免疫球蛋白和补体的免疫荧光沉积。给予甲泼尼龙“冲击”治疗（1000mg，静脉滴注，3天），随后逐渐减少类固醇剂量。所有患者蛋白尿减少，血尿消失。在随访期间，肾功能保持正常。
